The MBNA Wyeth Center at the Farnsworth Art Museum consists of several discrete components dedicated to collecting, research, exhibitions and interpretive programs related to three generations of Wyeths in Maine: N.C., Andrew, and James Wyeth. Exhibits focusing primarily on James Wyeth and N. C. Wyeth are presented at the "church" building on Union Street, an example of adaptive re-use of the United Methodist Church, one of Rockland's most prominent and venerable structures dating from the last quarter of the 19th century. Although major thematic shows occasionally present all three Wyeths at the church, the downstairs Linda Bean Folkers Gallery is primarily devoted to works by N.C. Wyeth while the upstairs, Marylouise Tandy Cowan Gallery usually presents works by James Wyeth. A new addition to the original museum building houses an extensive collection of temperas, watercolors, drybrush paintings and drawings by Andrew Wyeth. Rotating exhibits of Andrew Wyeth's work are largely drawn from this collection and are shown in the Study Center and adjacent Hadlock Galleries. Finally, a large Victorian house across from the church on Grace Street houses a separate research facility primarily devoted to James Wyeth but which also includes a basic information and standard reference materials related to all three generations of artists in Maine.

A unique component of the research facility as a whole is an interactive computer database program on the Wyeths in Maine. Designed for younger audiences, it includes virtual galleries that students can install with their own exhibitions as well as an extensive library of images and information that can be accessed in a variety of ways ranging from "tic-tac-toe" games to original articles scanned into the database (with permissions from all publishers). Located throughout the entire campus, computer kiosks allow visitors to the museum to experience the virtual world of the Wyeths.

Currently, primary and secondary research materials, including original works of art, photographs, ephemera and extensive bibliographic resources are being organized and catalogued toward eventual access by students, scholars, critics and scholars. Future plans include a Research Center for Maine Artists at the Farnsworth, centering on the these core Wyeth holdings but extending to many other artists, such as Jonathan Fisher, a minister and self-taught artist active in the early 19th century, and to Rockland's own Louise Nevelson, doyenne of post-World War II American sculptors.